Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC017
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-22 13:36
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 1/2+1/4+1/2+1/4 caps Madopar HBS a 125mg 1 uvece old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.66 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.66 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 31, 'TN': 24, 'TP': 11, 'FP': 6}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 22, 'TN': 16, 'TP': 20, 'FP': 14}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 3.644
timePerCircleCoV 0.149119
timePerCircleSlope -0.00924725
meanError 2.76545
tremorFreq 7.22656
tremorRelPower 20.5248
tremorGyroAmpMean 0.0841149
tremorGyroAmpSlope -0.0144619
tremorGyroAmpCoV 0.446915
tremorCoordAmpMean 0.165307
tremorCoordAmpSlope -0.0103357
tremorCoordAmpCoV 0.415398
tremorAccAmpMean 0.16253
tremorAccAmpSlope -0.0129335
tremorAccAmpCoV 0.438017
tremorPcRelVar 0.892237
tremorPcX 0.869675
tremorPcY -0.493625

Circle Segment 1

Duration 3.84 s, Accuracy Estimate 2.668 (lower is better)

Circle Segment 2

Duration 4.64 s, Accuracy Estimate 2.255 (lower is better)

Circle Segment 3

Duration 3.52 s, Accuracy Estimate 2.53 (lower is better)

Circle Segment 4

Duration 3.2 s, Accuracy Estimate 2.625 (lower is better)

Circle Segment 5

Duration 3.08 s, Accuracy Estimate 3.303 (lower is better)

Circle Segment 6

Duration 3.44 s, Accuracy Estimate 2.33 (lower is better)

Circle Segment 7

Duration 3.28 s, Accuracy Estimate 2.951 (lower is better)

Circle Segment 8

Duration 3.92 s, Accuracy Estimate 2.241 (lower is better)

Circle Segment 9

Duration 4.4 s, Accuracy Estimate 2.355 (lower is better)

Circle Segment 10

Duration 3.12 s, Accuracy Estimate 4.397 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 13.564
timePerSpiralCoV 0.0701372
timePerSpiralSlope -0.0156028
meanError 2.08543
tremorFreq 5.37109
tremorRelPower 22.3668
tremorGyroAmpMean 0.0844259
tremorGyroAmpSlope 0.000204496
tremorGyroAmpCoV 0.569726
tremorCoordAmpMean 0.221478
tremorCoordAmpSlope -0.00285316
tremorCoordAmpCoV 0.704349
tremorAccAmpMean 0.184865
tremorAccAmpSlope 0.00100877
tremorAccAmpCoV 0.48077
tremorPcRelVar 0.763221
tremorPcX 0.80626
tremorPcY 0.591561

Spiral Segment 1

Duration 13.96 s, Accuracy Estimate 1.78 (lower is better)

Spiral Segment 2

Duration 14.64 s, Accuracy Estimate 2.331 (lower is better)

Spiral Segment 3

Duration 15.56 s, Accuracy Estimate 1.941 (lower is better)

Spiral Segment 4

Duration 12.84 s, Accuracy Estimate 2.16 (lower is better)

Spiral Segment 5

Duration 13.64 s, Accuracy Estimate 2.169 (lower is better)

Spiral Segment 6

Duration 13.24 s, Accuracy Estimate 2.153 (lower is better)

Spiral Segment 7

Duration 12.92 s, Accuracy Estimate 2.058 (lower is better)

Spiral Segment 8

Duration 13.44 s, Accuracy Estimate 1.853 (lower is better)

Spiral Segment 9

Duration 12.32 s, Accuracy Estimate 2.259 (lower is better)

Spiral Segment 10

Duration 13.08 s, Accuracy Estimate 2.151 (lower is better)

Elel

eDurationMean 0.461154
eDurationStd 0.0845846
eDurationStdnorm 0.183419
eDurationMedian 0.46
eDurationQuartdelta 0.15125
eDurationQuartdeltanorm 0.328804
eDurationKurt 1.97688
eDurationTrenddiff -0.03
eDurationTrendratio 0.934783
eWidthMean 6.297
eWidthStd 1.89645
eWidthStdnorm 0.301167
eWidthMedian 6.552
eWidthQuartdelta 2.48625
eWidthQuartdeltanorm 0.379464
eWidthKurt 3.34066
eWidthTrenddiff -0.702
eWidthTrendratio 0.9
eHeightMean 13.209
eHeightStd 2.29928
eHeightStdnorm 0.174069
eHeightMedian 13.104
eHeightQuartdelta 2.925
eHeightQuartdeltanorm 0.223214
eHeightKurt 2.84838
eHeightTrenddiff -0.585
eHeightTrendratio 0.956522
eAspectMean 0.49125
eAspectStd 0.17865
eAspectStdnorm 0.363665
eAspectMedian 0.477612
eAspectQuartdelta 0.215306
eAspectQuartdeltanorm 0.450797
eAspectKurt 2.8022
eAspectTrenddiff -0.0538231
eAspectTrendratio 0.891486
eSlantMean -0.148179
eSlantStd 0.278026
eSlantStdnorm -1.87628
eSlantMedian -0.160714
eSlantQuartdelta 0.37424
eSlantQuartdeltanorm -2.3286
eSlantKurt 2.57935
eSlantTrenddiff 0.0840979
eRtopMean 0.629049
eRtopStd 0.27773
eRtopStdnorm 0.441508
eRtopMedian 0.657143
eRtopQuartdelta 0.448421
eRtopQuartdeltanorm 0.68238
eRtopKurt 2.30382
eRtopTrenddiff -0.057971
eRbotMean 1.09294
eRbotStd 0.701537
eRbotStdnorm 0.641878
eRbotMedian 0.887324
eRbotQuartdelta 0.714124
eRbotQuartdeltanorm 0.804807
eRbotKurt 7.68482
eRbotTrenddiff -0.05
eRrightMean 0.865168
eRrightStd 0.0937659
eRrightStdnorm 0.108379
eRrightMedian 0.868687
eRrightQuartdelta 0.122222
eRrightQuartdeltanorm 0.140698
eRrightKurt 3.05636
eRrightTrenddiff 0.0198644
eRleftMean 0.553381
eRleftStd 0.218719
eRleftStdnorm 0.395241
eRleftMedian 0.544776
eRleftQuartdelta 0.284881
eRleftQuartdeltanorm 0.522932
eRleftKurt 2.11313
eRleftTrenddiff -0.0358056
lDurationMean 0.569861
lDurationStd 0.098695
lDurationStdnorm 0.173191
lDurationMedian 0.5575
lDurationQuartdelta 0.1475
lDurationQuartdeltanorm 0.264574
lDurationKurt 2.2392
lDurationTrenddiff 0.0025
lDurationTrendratio 1.00448
lWidthMean 7.21175
lWidthStd 1.57697
lWidthStdnorm 0.218666
lWidthMedian 7.137
lWidthQuartdelta 2.3985
lWidthQuartdeltanorm 0.336066
lWidthKurt 2.01622
lWidthTrenddiff -0.819
lWidthTrendratio 0.891473
lHeightMean 24.284
lHeightStd 3.69208
lHeightStdnorm 0.152038
lHeightMedian 24.5115
lHeightQuartdelta 4.6215
lHeightQuartdeltanorm 0.188544
lHeightKurt 2.55659
lHeightTrenddiff -3.276
lHeightTrendratio 0.873303
lAspectMean 0.303263
lAspectStd 0.0786468
lAspectStdnorm 0.259335
lAspectMedian 0.295064
lAspectQuartdelta 0.110937
lAspectQuartdeltanorm 0.375976
lAspectKurt 2.64325
lAspectTrenddiff 0.0122163
lAspectTrendratio 1.04181
lSlantMean -0.112236
lSlantStd 0.141956
lSlantStdnorm -1.2648
lSlantMedian -0.108804
lSlantQuartdelta 0.236579
lSlantQuartdeltanorm -2.17436
lSlantKurt 1.9844
lSlantTrenddiff -0.00409424
lRtopMean 0.52526
lRtopStd 0.245711
lRtopStdnorm 0.46779
lRtopMedian 0.611335
lRtopQuartdelta 0.360902
lRtopQuartdeltanorm 0.590351
lRtopKurt 2.34216
lRtopTrenddiff 0.0179837
lRbotMean 0.930113
lRbotStd 0.420785
lRbotStdnorm 0.452402
lRbotMedian 0.944752
lRbotQuartdelta 0.633082
lRbotQuartdeltanorm 0.670104
lRbotKurt 2.2949
lRbotTrenddiff 0.0458296
lRrightMean 0.793409
lRrightStd 0.118743
lRrightStdnorm 0.149661
lRrightMedian 0.812364
lRrightQuartdelta 0.128732
lRrightQuartdeltanorm 0.158467
lRrightKurt 5.92601
lRrightTrenddiff -0.0199528
lRleftMean 0.653635
lRleftStd 0.224177
lRleftStdnorm 0.342969
lRleftMedian 0.648248
lRleftQuartdelta 0.414584
lRleftQuartdeltanorm 0.639545
lRleftKurt 1.9475
lRleftTrenddiff -0.0488064

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.604722
sumTouchScores 19.3511
meanMovementTime 0.617903
numTouches 32
undershootPercentage 3.125
overshootPercentage 40.625

FITTS Long Modified

meanTouchScore 0.653008
sumTouchScores 16.3252
meanMovementTime 0.802708
numTouches 25
undershootPercentage 4
overshootPercentage 32

ZigZag

numZigzags 5
timePerZigzagMean 11.704
timePerZigzagCoV 0.070149
timePerZigzagSlope -0.0338346
meanError 3.49671
tremorFreq 5.76172
tremorRelPower 26.8545
tremorGyroAmpMean 0.0628851
tremorGyroAmpSlope -0.00176542
tremorGyroAmpCoV 0.361592
tremorCoordAmpMean 0.230816
tremorCoordAmpSlope 0.00590845
tremorCoordAmpCoV 1.27151
tremorAccAmpMean 0.136725
tremorAccAmpSlope -0.000308453
tremorAccAmpCoV 0.26119
tremorPcRelVar 0.841511
tremorPcX -0.243582
tremorPcY 0.96988

ZigZag Segment 1

Duration 12.08 s, Accuracy Estimate 3.413 (lower is better)

ZigZag Segment 2

Duration 12.96 s, Accuracy Estimate 3.246 (lower is better)

ZigZag Segment 3

Duration 11.24 s, Accuracy Estimate 3.934 (lower is better)

ZigZag Segment 4

Duration 11.32 s, Accuracy Estimate 3.431 (lower is better)

ZigZag Segment 5

Duration 10.92 s, Accuracy Estimate 3.459 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 9.464
timePerZigzagCoV 0.112127
timePerZigzagSlope -0.0532544
zigzagHeightMean 66.2761
zigzagHeightCoV 0.0310566
zigzagHeightSlope 0.015272
meanError 0.0418886
tremorFreq 5.17578
tremorRelPower 29.6372
tremorGyroAmpMean 0.108501
tremorGyroAmpSlope -0.00987161
tremorGyroAmpCoV 0.3327
tremorCoordAmpMean 0.184649
tremorCoordAmpSlope -0.00073773
tremorCoordAmpCoV 0.432018
tremorAccAmpMean 0.142199
tremorAccAmpSlope -0.00546574
tremorAccAmpCoV 0.56833
tremorPcRelVar 0.655072
tremorPcX 0.532563
tremorPcY 0.846391

ZigZag Offset Segment 1

Duration 9.72 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 2

Duration 10.4 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 3

Duration 10.08 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 4

Duration 9.44 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 5

Duration 7.68 s, Accuracy Estimate 0.056 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.73}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.66}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.8032071656087838}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9231951901729625}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}